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Proteomics associated with coronary high-risk plaques by optical coherence tomography.
Niida, Takayuki; Yuki, Haruhito; Suzuki, Keishi; Kinoshita, Daisuke; Fujimoto, Daichi; Nakajima, Akihiro; McNulty, Iris; Lee, Hang; Tanriverdi, Kahraman; Nakamura, Sunao; Jang, Ik-Kyung.
Afiliação
  • Niida T; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Yuki H; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Suzuki K; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Kinoshita D; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Fujimoto D; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Nakajima A; Interventional Cardiology Unit, New Tokyo Hospital, Chiba, Japan.
  • McNulty I; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Lee H; Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Tanriverdi K; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Nakamura S; Interventional Cardiology Unit, New Tokyo Hospital, Chiba, Japan.
  • Jang IK; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. ijang@mgh.harvard.edu.
J Thromb Thrombolysis ; 57(2): 204-211, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38296868
ABSTRACT
Biomarkers are widely used for the diagnosis and monitoring of cardiovascular disease. However, markers for coronary high-risk plaques have not been identified. The aim of this study was to identify proteins specific to coronary high-risk plaques. Fifty-one patients (71.2 ± 11.1 years, male 66.7%) who underwent intracoronary optical coherence tomography imaging and provided blood specimens for proteomic analysis were prospectively enrolled. A total of 1470 plasma proteins were analyzed per patient using the Olink® Explore 1536 Reagent Kit. In patients with thin-cap fibroatheroma, the protein expression of Calretinin (CALB2), Corticoliberin (CRH) and Alkaline phosphatase, placental type (ALPP) were significantly increased, while the expression of Neuroplastin (NPTN), Folate receptor gamma (FOLR3) and Serpin A12 (SERPINA12) were significantly decreased. In patients with macrophage infiltration, the protein expressions of Fatty acid-binding protein, intestinal (FABP2), and Fibroblast growth factor 21 (FGF21) were significantly decreased. In patients with lipid-rich plaques, the protein expression of Interleukin-17 C (IL17C) was significantly increased, while the expression of Fc receptor-like protein 3 (FCRL3) was significantly decreased. These proteins might be useful markers in identifying patients with coronary high-risk plaques. Clinical Trial Registration https//www.umin.ac.jp/ctr/ , UMIN000041692.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Serpinas / Placa Aterosclerótica Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Pregnancy Idioma: En Revista: J Thromb Thrombolysis Assunto da revista: ANGIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Serpinas / Placa Aterosclerótica Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Pregnancy Idioma: En Revista: J Thromb Thrombolysis Assunto da revista: ANGIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos