Smaller anterior hippocampal subfields in the early stage of psychosis.
Transl Psychiatry
; 14(1): 69, 2024 Jan 31.
Article
em En
| MEDLINE
| ID: mdl-38296964
ABSTRACT
Hippocampal volume is smaller in schizophrenia, but it is unclear when in the illness the changes appear and whether specific regions (anterior, posterior) and subfields (CA1, CA2/3, dentate gyrus, subiculum) are affected. Here, we used a high-resolution T2-weighted sequence specialized for imaging hippocampal subfields to test the hypothesis that anterior CA1 volume is lower in early psychosis. We measured subfield volumes across hippocampal regions in a group of 90 individuals in the early stage of a non-affective psychotic disorder and 70 demographically similar healthy individuals. We observed smaller volume in the anterior CA1 and dentate gyrus subfields in the early psychosis group. Our findings support models that implicate anterior CA1 and dentate gyrus subfield deficits in the mechanism of psychosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Esquizofrenia
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Transl Psychiatr
/
Transl Psychiatry
/
Translational psychiatry
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos