LETd Optimization Verification With an SOI Microdosimeter.
Int J Radiat Oncol Biol Phys
; 119(3): 946-956, 2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38300188
ABSTRACT
PURPOSE:
A first of its kind experimental verification of dose-averaged linear energy transfer (LETd) optimized treatment plans for proton therapy has been carried out using a silicon-on-insulator microdosimeter at the Massachusetts General Hospital (MGH), Boston, USA. METHODS AND MATERIALS Three clinical treatment plans of a typical ependymoma structure set were designed using the standard clinical approach, the proposed protocol approach, and a one-field approach. The plans were then reoptimized to reduce the LETd-weighted dose in the brain stem. All six plans were delivered in a solid water phantom and the experimental yDâ¾ measured.RESULTS:
After LETd optimization, a reduction in yDâ¾ was found within the brain stem by an average of 12%, 19%, and 4% for the clinical, protocol, and one-field plans, respectively, while maintaining adequate coverage of the tumor structure. The experimental LETd-weighted doses were in agreement with the treatment planning system calculations and Monte Carlo simulations and reinforced the improvement of the optimization.CONCLUSIONS:
This work demonstrates the first experimental verification of the clinical implementation of LETd optimization for patient treatment with proton therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dosagem Radioterapêutica
/
Planejamento da Radioterapia Assistida por Computador
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Neoplasias Encefálicas
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Método de Monte Carlo
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Transferência Linear de Energia
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Imagens de Fantasmas
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Ependimoma
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Terapia com Prótons
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Revista:
Int J Radiat Oncol Biol Phys
Ano de publicação:
2024
Tipo de documento:
Article