DNA repair, gap suppression, or fork protection: BRCA2 needs a break!

Dibitetto, Diego; Rottenberg, Sven

Dibitetto, Diego; Rottenberg, Sven.

Afiliação

Dibitetto D; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Langgassstrasse 122, 3012 Bern, Switzerland; Bern Center for Precision Medicine and Cancer Therapy Research Cluster, 3012 Bern, Switzerland.
Rottenberg S; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Langgassstrasse 122, 3012 Bern, Switzerland; Bern Center for Precision Medicine and Cancer Therapy Research Cluster, 3012 Bern, Switzerland. Electronic address: sven.rottenberg@unibe.ch.

Mol Cell ; 84(3): 409-410, 2024 Feb 01.

Article em En | MEDLINE | ID: mdl-38307000

ABSTRACT

ABSTRACT

In this issue of Molecular Cell, Lim et al.1 reveal new insights into the distinct roles of BRCA2 in coping with DNA breaks, highlighting homologous recombination as the pivotal function that affects tumorigenesis and therapy response.

Assuntos

Replicação do DNA; Rad51 Recombinase; Proteína BRCA2/genética; Proteína BRCA2/metabolismo; Quebras de DNA; Reparo do DNA; Recombinação Homóloga/genética; Rad51 Recombinase/genética; Humanos; Animais; Camundongos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Replicação do DNA / Rad51 Recombinase Limite: Animals / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suíça

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google