Scale based entropy measures and deep learning methods for analyzing the dynamical characteristics of cardiorespiratory control system in COVID-19 subjects during and after recovery.

ABSTRACT

COVID-19, known as Coronavirus Disease 2019 primarily targets the respiratory system and can impact the cardiovascular system, leading to a range of cardiorespiratory complications. The current forefront in analyzing the dynamical characteristics of physiological systems and aiding clinical decision-making involves the integration of entropy-based complexity techniques with artificial intelligence. Entropy-based measures offer promising prospects for identifying disturbances in cardiorespiratory control system (CRCS) among COVID-19 patients by assessing the oxygen saturation variability (OSV) signals. In this investigation, we employ scale-based entropy (SBE) methods, including multiscale entropy (MSE), multiscale permutation entropy (MPE), and multiscale fuzzy entropy (MFE), to characterize the dynamical characteristics of OSV signals. These measurements serve as features for the application of traditional machine learning (ML) and deep learning (DL) approaches in the context of classifying OSV signals from COVID-19 patients during their illness and subsequent recovery. We use the Beurer PO-80 pulse oximeter which non-invasively acquired OSV and pulse rate data from COVID-19 infected patients during the active infection phase and after a two-month recovery period. The dataset comprises of 88 recordings collected from 44 subjects(26 men and 18 women), both during their COVID-19 illness and two months post-recovery. Prior to analysis, data preprocessing is performed to remove artifacts and outliers. The application of SBE measures to OSV signals unveils a reduction in signal complexity during the course of COVID-19. Leveraging these SBE measures as feature sets, we employ two DL techniques, namely the radial basis function network (RBFN) and RBFN with dynamic delay algorithm (RBFNDDA), for the classification of OSV data collected during and after COVID-19 recovery. To evaluate the classification performance, we employ standard metrics such as sensitivity, specificity, false positive rate (FPR), and the area under the receiver operator characteristic curve (AUC). Among the three scale-based entropy measures, MFE outperformed MSE and MPE by achieving the highest classification performance using RBFN with 13 best features having sensitivity (0.84), FPR (0.30), specificity (0.70) and AUC (0.77). The outcomes of our study demonstrate that SBE measures combined with DL methods offer a valuable approach for categorizing OSV signals obtained during and after COVID-19, ultimately aiding in the detection of CRCS dysfunction.