Sweet dreams: glycosylation controls tumor cell dormancy.
Trends Cancer
; 10(3): 180-181, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38311543
ABSTRACT
In a recent study in Cancer Cell, Sreekumar et al. used therapy-associated breast cancer mouse models as well as in vitro dormancy models to identify extracellular matrix (ECM)-related tumor cell-autonomous mechanisms of dormancy in residual tumor cells (RTCs). The study reveals an important role of the glycosylation of proteoglycans in sustaining dormancy and opens the door to leverage this biology to eliminate RTCs and prevent recurrence.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Matriz Extracelular
Limite:
Animals
Idioma:
En
Revista:
Trends Cancer
/
Trends in cancer (Online)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos