A high dietary acid load can potentially exacerbate cardiometabolic risk factors: An updated systematic review and meta-analysis of observational studies.
Nutr Metab Cardiovasc Dis
; 34(3): 569-580, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38316575
ABSTRACT
AIMS:
Chronic metabolic acidosis has been shown to be associated with cardiometabolic risk factors. The aim of the currently updated meta-analysis was to explore the association between Potential Renal Acid Load (PRAL) and Net Endogenous Acid Production (NEAP) with these risk factors. DATASYNTHESIS:
Databases were searched up to May 2023. The mean of waist circumference (WC), body mass index (BMI), high- and low-density lipoprotein-cholesterol (HDL-C and LDL-C), triglyceride (TG), total cholesterol (TC), fasting blood sugar (FBS), and systolic- and diastolic blood pressure (SBP and DBP) in highest category vs lowest categories of NEAP and PRAL were recorded. Effect sizes were generated as weighted mean difference (WMD). Results showed that SBP, DBP, and WC had a significant difference in the upper and lower categories of PRAL (WMDSBP 1.466 mmHg; 95% CI 2.121, -0.811; P<0.001, WMDDBP 0.710 mmHg; 95 % CI 1.170, -0.249; P=0.003, and WMDWC 0.819 cm; 95% CI 1.446, -0.192; P=0.010) or NEAP (WMDSBP 1.690 mmHg; 95% CI 2.789, -0.591; P=0.003, WMDDBP 1.076 mmHg, and WMDWC 1.325 cm; 95% CI 1.901, -0.749; P<0.001; 95% CI 1.938, -0.214; P =0.014). The lowest versus highest categories of dietary PRAL were associated with lower BMI (WMDPRAL 0.297 kg/m2; 95 % CI 0.440, -0.154; P<0.001) and TG (WMD 2.280 mg/dl; 95%CI 3.828, -0.732; P=0.004; I2=99.4 %; P<0.001).CONCLUSIONS:
High DAL can be considered as an independent risk factor for increasing anthropometric indices, blood pressure, and TG. This study registered in the PROSPERO database (Registration No. CRD42023402985).Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Dieta
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Nutr Metab Cardiovasc Dis
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
CIENCIAS DA NUTRICAO
/
METABOLISMO
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Irã