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Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction.
Zhang, Shuang; Paccalet, Alexandre; Rohde, David; Cremer, Sebastian; Hulsmans, Maarten; Lee, I-Hsiu; Mentkowski, Kyle; Grune, Jana; Schloss, Maximilian J; Honold, Lisa; Iwamoto, Yoshiko; Zheng, Yi; Bredella, Miriam A; Buckless, Colleen; Ghoshhajra, Brian; Thondapu, Vikas; van der Laan, Anja M; Piek, Jan J; Niessen, Hans W M; Pallante, Fabio; Carnevale, Raimondo; Perrotta, Sara; Carnevale, Daniela; Iborra-Egea, Oriol; Muñoz-Guijosa, Christian; Galvez-Monton, Carolina; Bayes-Genis, Antoni; Vidoudez, Charles; Trauger, Sunia A; Scadden, David; Swirski, Filip K; Moskowitz, Michael A; Naxerova, Kamila; Nahrendorf, Matthias.
Afiliação
  • Zhang S; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Paccalet A; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Rohde D; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Cremer S; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Hulsmans M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Lee IH; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Mentkowski K; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Grune J; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Schloss MJ; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Honold L; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Iwamoto Y; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Zheng Y; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Bredella MA; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Buckless C; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Ghoshhajra B; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Thondapu V; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • van der Laan AM; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Piek JJ; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Niessen HWM; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Pallante F; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Carnevale R; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Perrotta S; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Carnevale D; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Iborra-Egea O; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Muñoz-Guijosa C; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Galvez-Monton C; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Bayes-Genis A; Department of Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • Vidoudez C; Department of Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • Trauger SA; Department of Pathology and Cardiac Surgery, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands.
  • Scadden D; Department of AngioCardioNeurology and Translational Medicine, I.R.C.C.S. INM Neuromed, Pozzilli, Italy.
  • Swirski FK; Department of AngioCardioNeurology and Translational Medicine, I.R.C.C.S. INM Neuromed, Pozzilli, Italy.
  • Moskowitz MA; Department of AngioCardioNeurology and Translational Medicine, I.R.C.C.S. INM Neuromed, Pozzilli, Italy.
  • Naxerova K; Department of AngioCardioNeurology and Translational Medicine, I.R.C.C.S. INM Neuromed, Pozzilli, Italy.
  • Nahrendorf M; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Nat Cardiovasc Res ; 2(12): 1277-1290, 2023 Dec.
Article em En | MEDLINE | ID: mdl-38344689
ABSTRACT
After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart failure. Since the balance between glycolysis and mitochondrial metabolism regulates hematopoietic stem cell homeostasis, metabolic cues may influence emergency myelopoiesis. Here, we show in humans and female mice that hematopoietic progenitor cells increase fatty acid metabolism after MI. Blockade of fatty acid oxidation by deleting carnitine palmitoyltransferase (Cpt1A) in hematopoietic cells of Vav1Cre/+Cpt1Afl/fl mice limited hematopoietic progenitor proliferation and myeloid cell expansion after MI. We also observed reduced bone marrow adiposity in humans, pigs and mice following MI. Inhibiting lipolysis in adipocytes using AdipoqCreERT2Atglfl/fl mice or local depletion of bone marrow adipocytes in AdipoqCreERT2iDTR mice also curbed emergency hematopoiesis. Furthermore, systemic and regional sympathectomy prevented bone marrow adipocyte shrinkage after MI. These data establish a critical role for fatty acid metabolism in post-MI emergency hematopoiesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Cardiovasc Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Cardiovasc Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos