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Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma.
Tang, Shaoshuai; Wang, Yunzhi; Luo, Rongkui; Fang, Rundong; Liu, Yufeng; Xiang, Hang; Ran, Peng; Tong, Yexin; Sun, Mingjun; Tan, Subei; Huang, Wen; Huang, Jie; Lv, Jiacheng; Xu, Ning; Yao, Zhenmei; Zhang, Qiao; Xu, Ziyan; Yue, Xuetong; Yu, Zixiang; Akesu, Sujie; Ding, Yuqin; Xu, Chen; Lu, Weiqi; Zhou, Yuhong; Hou, Yingyong; Ding, Chen.
Afiliação
  • Tang S; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Wang Y; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Luo R; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Fang R; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Liu Y; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Xiang H; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Ran P; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Tong Y; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Sun M; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Tan S; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Huang W; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Huang J; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Lv J; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Xu N; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Yao Z; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Zhang Q; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Xu Z; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Yue X; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences, Human Phenome Institute, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200433, China.
  • Yu Z; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Akesu S; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Ding Y; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Xu C; Shanghai Institute of Medical Imaging, Shanghai, China.
  • Lu W; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China. xu.chen@zs-hospital.sh.cn.
  • Zhou Y; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. Lu.weiqi@zs-hospital.sh.cn.
  • Hou Y; Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China. zhou.yuhong@zs-hospital.sh.cn.
  • Ding C; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China. hou.yingyong@zs-hospital.sh.cn.
Nat Commun ; 15(1): 1381, 2024 Feb 15.
Article em En | MEDLINE | ID: mdl-38360860
ABSTRACT
Soft tissue sarcoma is a broad family of mesenchymal malignancies exhibiting remarkable histological diversity. We portray the proteomic landscape of 272 soft tissue sarcomas representing 12 major subtypes. Hierarchical classification finds the similarity of proteomic features between angiosarcoma and epithelial sarcoma, and elevated expression of SHC1 in AS and ES is correlated with poor prognosis. Moreover, proteomic clustering classifies patients of soft tissue sarcoma into 3 proteomic clusters with diverse driven pathways and clinical outcomes. In the proteomic cluster featured with the high cell proliferation rate, APEX1 and NPM1 are found to promote cell proliferation and drive the progression of cancer cells. The classification based on immune signatures defines three immune subtypes with distinctive tumor microenvironments. Further analysis illustrates the potential association between immune evasion markers (PD-L1 and CD80) and tumor metastasis in soft tissue sarcoma. Overall, this analysis uncovers sarcoma-type-specific changes in proteins, providing insights about relationships of soft tissue sarcoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma / Neoplasias de Tecidos Moles / Hemangiossarcoma Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma / Neoplasias de Tecidos Moles / Hemangiossarcoma Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China