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Pd(II)-Catalyzed ß-C(sp3)-H Alkynylation of Alanine in Di- and Tripeptides with Asn as an Endogenous Directing Group.
Ding, Xing-Xing; Ren, Bo-Quan; Li, Bing-Tong; Pang, Zhao-Jiong; Xu, Yan-Jun; Dong, Lin.
Afiliação
  • Ding XX; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Ren BQ; College of Chemistry and Material Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
  • Li BT; College of Chemistry and Material Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
  • Pang ZJ; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Xu YJ; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Dong L; College of Chemistry and Material Science, Sichuan Normal University, Chengdu, Sichuan 610066, China.
J Org Chem ; 89(5): 3390-3402, 2024 03 01.
Article em En | MEDLINE | ID: mdl-38377557
ABSTRACT
The introduction of alkyne moieties into peptides remains in demand as it represents a promising approach for further structural diversification of peptides. Herein, we describe the Pd(II)-catalyzed C(sp3)-H alkynylation of Ala-Asn-embedded di- and tripeptides using Asn as the endogenous lead group. In addition, a key building block for the glycopeptide Tyc4PG-14 and Tyc4PG-15 was produced by our methodology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alanina / Alcinos Idioma: En Revista: J Org Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alanina / Alcinos Idioma: En Revista: J Org Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China