Keeping Your Brain in Balance: Homeostatic Regulation of Network Function.
Annu Rev Neurosci
; 47(1): 41-61, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38382543
ABSTRACT
To perform computations with the efficiency necessary for animal survival, neocortical microcircuits must be capable of reconfiguring in response to experience, while carefully regulating excitatory and inhibitory connectivity to maintain stable function. This dynamic fine-tuning is accomplished through a rich array of cellular homeostatic plasticity mechanisms that stabilize important cellular and network features such as firing rates, information flow, and sensory tuning properties. Further, these functional network properties can be stabilized by different forms of homeostatic plasticity, including mechanisms that target excitatory or inhibitory synapses, or that regulate intrinsic neuronal excitability. Here we discuss which aspects of neocortical circuit function are under homeostatic control, how this homeostasis is realized on the cellular and molecular levels, and the pathological consequences when circuit homeostasis is impaired. A remaining challenge is to elucidate how these diverse homeostatic mechanisms cooperate within complex circuits to enable them to be both flexible and stable.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Homeostase
/
Rede Nervosa
/
Plasticidade Neuronal
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Neurosci
Ano de publicação:
2024
Tipo de documento:
Article