Facile Friedel-Crafts alkylation of arenes under solvent-free conditions.

Chen, Feijing; Zhao, Xiao-Xiao; Zhang, Hao-Tian; Ma, Yan-Na; Chen, Xuenian

Chen, Feijing; Zhao, Xiao-Xiao; Zhang, Hao-Tian; Ma, Yan-Na; Chen, Xuenian.

Afiliação

Chen F; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, Henan, China. mayanna@zzu.edu.cn.
Zhao XX; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, Henan, China. mayanna@zzu.edu.cn.
Zhang HT; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, Henan, China. mayanna@zzu.edu.cn.
Ma YN; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, Henan, China. mayanna@zzu.edu.cn.
Chen X; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, Henan, China. mayanna@zzu.edu.cn.

Org Biomol Chem ; 22(11): 2187-2191, 2024 Mar 13.

Article em En | MEDLINE | ID: mdl-38391292

ABSTRACT

ABSTRACT

The Friedel-Crafts alkylation of arenes is an important part of electrophilic aromatic substitution reactions. However, the reactivity of arenes is weakened by electron-withdrawing substituents, leading to limited substrate scopes and applications. Herein, we developed an efficient HOTf-promoted Friedel-Crafts alkylation reaction of broad arenes with α-aryl-α-diazoesters under metal-free and solvent-free conditions.

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google