Oncogenic MTOR Signaling Axis Compensates BTK Inhibition in a Chronic Lymphocytic Leukemia Patient with Richter Transformation: A Case Report and Review of the Literature.
Acta Haematol
; 147(5): 604-611, 2024.
Article
em En
| MEDLINE
| ID: mdl-38402867
ABSTRACT
INTRODUCTION:
Targeting the B-cell receptor pathway via ibrutinib, a specific inhibitor of Bruton's tyrosine kinase, has shown marked clinical efficacy in treatment of patients with chronic lymphocytic leukemia (CLL), thus becoming a preferred first line option independent of risk factors. However, acquired resistance to ibrutinib poses a major clinical problem and requires the development of novel treatment combinations to increase efficacy and counteract resistance development and clinical relapse rates. CASE PRESENTATION In this study, we performed exome and transcriptome analyses of an ibrutinib resistant CLL patient in order to investigate genes and expression patterns associated with ibrutinib resistance. Here, we provide evidence that ibrutinib resistance can be attributed to aberrant mammalian target of rapamycin (MTOR) signaling.CONCLUSION:
Thus, our study proposes that combined use of MTOR inhibitors with ibrutinib could be a possible option to overcome therapy resistance in ibrutinib treated patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Adenina
/
Leucemia Linfocítica Crônica de Células B
/
Transdução de Sinais
/
Resistencia a Medicamentos Antineoplásicos
/
Inibidores de Proteínas Quinases
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Serina-Treonina Quinases TOR
/
Tirosina Quinase da Agamaglobulinemia
Limite:
Humans
/
Male
Idioma:
En
Revista:
Acta Haematol
Ano de publicação:
2024
Tipo de documento:
Article