Your browser doesn't support javascript.
loading
mADRES predicts hepatocellular carcinoma development in patients with hepatitis C virus who achieved sustained virological response.
Tada, Toshifumi; Kumada, Takashi; Hiraoka, Atsushi; Kariyama, Kazuya; Yasuda, Satoshi; Tada, Fujimasa; Ohama, Hideko; Nouso, Kazuhiro; Matono, Tomomitsu; Nakamura, Shinichiro; Toyoda, Hidenori.
Afiliação
  • Tada T; Department of Internal Medicine, Japanese Red Cross Society Himeji Hospital, Himeji, Japan.
  • Kumada T; Department of Nursing, Gifu Kyoritsu University, Gifu, Japan.
  • Hiraoka A; Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.
  • Kariyama K; Department of Gastroenterology, Okayama City Hospital, Okayama, Japan.
  • Yasuda S; Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan.
  • Tada F; Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.
  • Ohama H; Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.
  • Nouso K; Department of Gastroenterology, Okayama City Hospital, Okayama, Japan.
  • Matono T; Department of Internal Medicine, Himeji St. Mary's Hospital, Himeji, Japan.
  • Nakamura S; Department of Gastroenterology, Hyogo Prefectural Harima-Himeji General Medical Center, Himeji, Japan.
  • Toyoda H; Department of Internal Medicine, Japanese Red Cross Society Himeji Hospital, Himeji, Japan.
J Gastroenterol Hepatol ; 39(6): 1164-1171, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38403468
ABSTRACT
BACKGROUND AND

AIM:

The study aims to develop a novel predictive model including the fibrosis (FIB)-3 index for hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C virus (HCV) who achieved sustained virological response (SVR) with direct-acting antiviral (DAA) therapy.

METHODS:

This study included 2529 patients in whom HCV was eradicated with DAA therapy. The after DAA recommendation for surveillance (ADRES) score, which is based on sex, FIB-4 index, and α-fetoprotein, was used to predict HCC development. We developed a modified ADRES (mADRES) score, in which the FIB-4 index was replaced by the FIB-3 index, and evaluated its usefulness in predicting HCC development compared with the ADRES score.

RESULTS:

In the training set (n = 1770), multivariate analysis with Cox proportional hazards modeling showed that male sex (hazard ratio [HR], 2.11; 95% confidence interval [CI], 1.48-3.01), FIB-3 index (HR, 1.36; 95% CI, 1.28-1.45), and α-fetoprotein (HR, 1.05; 95% CI, 1.03-1.07) are independently associated with HCC development. The incidence of HCC differed significantly by ADRES or mADRES score in multiple comparisons. Univariate Cox proportional hazards models showed that compared with the mADRES score 0 group, the HR for HCC development was 2.07 (95% CI, 1.02-4.19) for the mADRES score 1 group, 11.37 (95% CI, 5.80-22.27) for the mADRES score 2 group, and 21.95 (95% CI, 10.17-47.38) for the mADRES score 3 group. Similar results were obtained for mADRES score but not for ADRES score in the validation set (n = 759).

CONCLUSION:

The mADRES score is useful for predicting HCC development after SVR.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Alfa-Fetoproteínas / Carcinoma Hepatocelular / Hepatite C Crônica / Resposta Viral Sustentada / Neoplasias Hepáticas Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Gastroenterol Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Alfa-Fetoproteínas / Carcinoma Hepatocelular / Hepatite C Crônica / Resposta Viral Sustentada / Neoplasias Hepáticas Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Gastroenterol Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão