Urinary concentration of Cathepsin D as a relievable marker of preeclampsia.
Pregnancy Hypertens
; 36: 101116, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38408407
ABSTRACT
BACKGROUND:
The early and accurate diagnosis of preeclampsia is crucial to avoid serious complications for both the mother and baby. However, the current diagnostic methods are limited, and there is a need for new diagnostic biomarkers. Previous studies have shown that cathepsin D (CTD) participates in the pathophysiology of preeclampsia and is present in urine samples, making it a potential biomarker for the disease. This study aimed to compare urinary and serum levels of CTD in preeclamptic and normotensive women and analyze its potential role as a diagnostic biomarker in preeclampsia.METHODS:
The study included thirty-nine patients with preeclampsia and twelve normotensive pregnant women as controls. Biomarkers were determined using Multiplex Assay kit, and serum prolactin (Prl) and urinary TNF-α levels were also evaluated. Statistical analysis was conducted using the Mann-Whitney U test.RESULTS:
We found that urinary and serum CTD levels were significantly higher in the preeclampsia group than in the normotensive group, suggesting that CTD could be a diagnostic biomarker for preeclampsia. No significant differences were found in the levels of serum prolactin or urinary TNF-α between the two groups.CONCLUSIONS:
The study provides evidence that non-invasive biological samples such as urine can be used to improve new therapeutic strategies for the early management of preeclampsia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Prolactina
/
Biomarcadores
/
Catepsina D
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Pregnancy Hypertens
Ano de publicação:
2024
Tipo de documento:
Article