Cytomegalovirus Cell-mediated Immunity Assays in Pediatric Transplantation.
J Pediatric Infect Dis Soc
; 13(Supplement_1): S22-S30, 2024 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-38417088
ABSTRACT
Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in pediatric transplantation. However, currently utilized CMV prevention paradigms have limitations, leading to research aimed at novel strategies for mitigation of CMV infection. Cell-mediated immunity (CMI) is crucial in controlling CMV infection and the use of CMV-specific CMI assays to guide prevention and treatment of CMV infection in both solid organ transplant and hematopoietic cell transplant recipients shows great promise. In this article, we review the immune response to CMV infection to highlight the rationale for CMI assays, describe available commercial assays and strategies for their use, and summarize relevant literature regarding the use of CMI assays in transplant recipients.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Órgãos
/
Infecções por Citomegalovirus
/
Transplante de Células-Tronco Hematopoéticas
Limite:
Child
/
Humans
Idioma:
En
Revista:
J Pediatric Infect Dis Soc
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos