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High resolution dynamic ultrasound atlas of embryonic and fetal development of the common marmoset.
Soman, Rohan R; Fabiszak, Margaret M; McPhee, Michael; Schade, Peter; Freiwald, Winrich; Brivanlou, Ali H.
Afiliação
  • Soman RR; Tri-Institutional MD-PhD Program, Weill Cornell Medical College, New York, NY, USA.
  • Fabiszak MM; Laboratory of Synthetic Embryology, Rockefeller University, New York, NY, USA.
  • McPhee M; Tri-Institutional MD-PhD Program, Weill Cornell Medical College, New York, NY, USA.
  • Schade P; Laboratory of Neural Systems, Rockefeller University, New York, NY, USA.
  • Freiwald W; Laboratory of Neural Systems, Rockefeller University, New York, NY, USA.
  • Brivanlou AH; Laboratory of Neural Systems, Rockefeller University, New York, NY, USA.
J Assist Reprod Genet ; 41(5): 1319-1328, 2024 May.
Article em En | MEDLINE | ID: mdl-38446290
ABSTRACT

PURPOSE:

The common marmoset (Callithrix jacchus) provides an ideal model to study early development of primates, and an in vivo platform to validate conclusions from in vitro studies of human embryos and embryo models. Currently, however, no established staging atlas of marmoset embryonic development exists. Using high-resolution, longitudinal ultrasound scans on live pregnant marmosets, we present the first dynamic in vivo imaging of entire primate gestation beginning with attachment until the last day before birth.

METHODS:

Our study unveils the first dynamic images of an in vivo attached mammalian embryo developing in utero, and the intricacies of the delayed development period unique to the common marmoset amongst primates, revealing a window for somatic interventions.

RESULTS:

Established obstetric and embryologic measurements for each scan were used comparatively with the standardized Carnegie staging of human development to highlight similarities and differences. Our study also allows for tracking the development of major organs. We focus on the ontogeny of the primate heart and brain. Finally, input ultrasound images were used to train deep neural networks to accurately determine the gestational age. All our ultrasounds and staging data recording are posted online so that the atlas can be used as a community resource toward monitoring and managing marmoset breeding colonies.

CONCLUSION:

The temporal and spatial resolution of ultrasound achieved in this study demonstrates the promise of noninvasive imaging in the marmoset for the in vivo study of primate-specific aspects of embryonic and fetal development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Callithrix / Ultrassonografia Pré-Natal / Desenvolvimento Embrionário / Desenvolvimento Fetal Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: J Assist Reprod Genet Assunto da revista: GENETICA / MEDICINA REPRODUTIVA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Callithrix / Ultrassonografia Pré-Natal / Desenvolvimento Embrionário / Desenvolvimento Fetal Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: J Assist Reprod Genet Assunto da revista: GENETICA / MEDICINA REPRODUTIVA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos