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Cohort profile: The Copenhagen Analgesic Study-The COPANA cohort.
Fischer, Margit Bistrup; Mola, Gylli; Scheel, Lone; Wraae, Katrine Bak; Rom, Ane Lilleøre; Frederiksen, Hanne; Johannsen, Trine Holm; Almstrup, Kristian; Sundberg, Karin; Hegaard, Hanne Kristine; Juul, Anders; Hagen, Casper P.
Afiliação
  • Fischer MB; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Mola G; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Scheel L; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Wraae KB; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Rom AL; Department of Obstetrics, Center of Fetal Medicine and Pregnancy, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
  • Frederiksen H; Department of Obstetrics, Center of Fetal Medicine and Pregnancy, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
  • Johannsen TH; The Department of Obstetrics, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Almstrup K; Research Unit of Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Sundberg K; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Hegaard HK; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Juul A; Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Hagen CP; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Paediatr Perinat Epidemiol ; 38(4): 370-381, 2024 May.
Article em En | MEDLINE | ID: mdl-38453250
ABSTRACT

BACKGROUND:

Development of the gonads during fetal life is complex and vital for adult reproductive health. Cell and animal studies have shown an alarming effect of mild analgesics on germ cells in both males and females. More than 50% of pregnant women use mild analgesics during pregnancy, which potentially could compromise the reproductive health of the next generation.

OBJECTIVES:

We present a research protocol designed to evaluate the effect of prenatal exposure to mild analgesics and endocrine-disrupting chemicals on gonadal function in the offspring. POPULATION Healthy, singleton pregnant women and their partners.

DESIGN:

The COPANA cohort is a prospective, observational pregnancy and birth cohort.

METHODS:

Participants were enrolled during the first trimester of pregnancy. Information on the use of mild analgesics was collected retrospectively 3 months prior to pregnancy and prospectively every 2 weeks throughout the study. We collected extensive data on lifestyle and reproductive health. Biospecimens were collected in the first trimester (maternal and paternal urine- and blood samples), in the third trimester in conjunction with a study-specific ultrasound scan (maternal urine sample), and approximately 3 months post-partum during the infant minipuberty period (maternal and infant urine- and blood samples). A comprehensive evaluation of reproductive function in the infants during the minipuberty phase was performed, including an ultrasound scan of the testis or ovaries and uterus. PRELIMINARY

RESULTS:

In total, 685 pregnant women and their partners were included between March 2020 and January 2022. A total of 589 infants (287 males) and their parents completed the follow-up during the minipuberty phase (December 2020-November 2022).

CONCLUSIONS:

The Copenhagen Analgesic Study holds the potential to provide novel and comprehensive insights into the impact of early and late prenatal exposure to mild analgesics and other endocrine-disrupting chemicals on future reproductive function in the offspring.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Analgésicos Limite: Adult / Female / Humans / Male / Newborn / Pregnancy País/Região como assunto: Europa Idioma: En Revista: Paediatr Perinat Epidemiol Assunto da revista: EPIDEMIOLOGIA / PEDIATRIA / PERINATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Dinamarca

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Analgésicos Limite: Adult / Female / Humans / Male / Newborn / Pregnancy País/Região como assunto: Europa Idioma: En Revista: Paediatr Perinat Epidemiol Assunto da revista: EPIDEMIOLOGIA / PEDIATRIA / PERINATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Dinamarca