Total Synthesis of (±)-Rubriflordilactone A.
J Am Chem Soc
; 146(11): 7198-7203, 2024 Mar 20.
Article
em En
| MEDLINE
| ID: mdl-38456819
ABSTRACT
A new and efficient synthesis of rubriflordilactone A has been realized. The key transformations include the following (1) an intramolecular Prins cyclization to establish the seven-membered ring containing two contiguous stereocenters; (2) a Mukaiyama hydration/oxa-Michael cascade to construct the B-ring; and (3) an unprecedented stereocontrol intermolecular o-QM type [4 + 2]-cycloaddition to rapidly assemble core structure of rubriflordilactone A.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China