The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas.
Cancer Metastasis Rev
; 43(3): 977-980, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38466528
ABSTRACT
We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, characterized by a well-defined multigene signature including APOD, DCN, and LUM. This cell population has previously been labeled as consisting of inflammatory cancer-associated fibroblasts (iCAFs). The same signature characterizes naturally occurring fibro-adipogenic progenitors (FAPs) as well as stromal cells abundant in normal adipose tissue. Our analysis of human gene expression databases provides evidence that adipose stromal cells (ASCs) are recruited by tumors and undergo differentiation into CAFs during cancer progression to invasive and chemotherapy-resistant stages.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adipogenia
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Metastasis Rev
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos