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Glofitamab stimulates immune cell infiltration of CNS tumors and induces clinical responses in secondary CNS lymphoma.
Godfrey, James K; Gao, Lei; Shouse, Geoffrey; Song, Joo Y; Pak, Stacy; Lee, Brian; Chen, Bihong T; Kallam, Avyakta; Baird, John H; Marcucci, Guido; Ghoda, Lucy; Vauleon, Stephanie; Danilov, Alexey V; Herrera, Alex F; Kwak, Larry W; Budde, Lihua E.
Afiliação
  • Godfrey JK; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
  • Gao L; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
  • Shouse G; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
  • Song JY; Department of Pathology, City of Hope, Duarte, CA.
  • Pak S; Department of Pharmacy, City of Hope, Duarte, CA.
  • Lee B; Department of Pharmacy, City of Hope, Duarte, CA.
  • Chen BT; Department of Diagnostic Radiology, City of Hope, Duarte, CA.
  • Kallam A; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
  • Baird JH; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
  • Marcucci G; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
  • Ghoda L; Department of Hematological Malignancies and Translational Science, Beckman Research Institute of City of Hope, Duarte, CA.
  • Vauleon S; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Danilov AV; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
  • Herrera AF; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
  • Kwak LW; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
  • Budde LE; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
Blood ; 144(4): 457-461, 2024 Jul 25.
Article em En | MEDLINE | ID: mdl-38484137
ABSTRACT
ABSTRACT Although CD20×CD3 bispecific antibodies are effective against systemic B-cell lymphomas, their efficacy in central nervous system (CNS) lymphoma is unknown. Here, we report the CD20×CD3 bispecific glofitamab penetrates the blood-brain barrier, stimulates immune-cell infiltration of CNS tumors, and induces clinical responses in patients with secondary CNS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Sistema Nervoso Central / Anticorpos Biespecíficos Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Blood Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Sistema Nervoso Central / Anticorpos Biespecíficos Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Blood Ano de publicação: 2024 Tipo de documento: Article