Synaptic Plasticity and Cognitive Ability in Experimental Adult-Onset Hypothyroidism.
J Pharmacol Exp Ther
; 389(2): 150-162, 2024 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-38508752
ABSTRACT
Adult-onset hypothyroidism impairs normal brain function. Research on animal models of hypothyroidism has revealed critical information on how deficiency of thyroid hormones impacts the electrophysiological and molecular functions of the brain, which leads to the well known cognitive impairment in untreated hypothyroid patients. Currently, such information can only be obtained from experiments on animal models of hypothyroidism. This review summarizes important research findings that pertain to understanding the clinical cognitive consequences of hypothyroidism, which will provide a better guiding path for therapy of hypothyroidism. SIGNIFICANCE STATEMENT Cognitive impairment occurs during adult-onset hypothyroidism in both humans and animal models. Findings from animal studies validate clinical findings showing impaired long-term potentiation, decreased CaMKII, and increased calcineurin. Such findings can only be gleaned from animal experiments to show how hypothyroidism produces clinical symptoms.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipocampo
/
Hipotireoidismo
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Pharmacol Exp Ther
Ano de publicação:
2024
Tipo de documento:
Article