2024 Update on Classification, Etiology, and Typing of Renal Amyloidosis: A Review.
Am J Kidney Dis
; 84(3): 361-373, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38514011
ABSTRACT
Amyloidosis is a protein folding disease that causes organ injuries and even death. In humans, 42 proteins are now known to cause amyloidosis. Some proteins become amyloidogenic as a result of a pathogenic variant as seen in hereditary amyloidoses. In acquired forms of amyloidosis, the proteins form amyloid in their wild-type state. Four types (serum amyloid A, transthyretin, apolipoprotein A-IV, and ß2-macroglobulin) of amyloid can occur either as acquired or as a mutant. Iatrogenic amyloid from injected protein medications have also been reported and AIL1RAP (anakinra) has been recently found to involve the kidney. Finally, the mechanism of how leukocyte cell-derived chemotaxin 2 (ALECT2) forms amyloid remains unknown. This article reviews the amyloids that involve the kidney and how they are typed.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amiloidose
/
Nefropatias
Limite:
Humans
Idioma:
En
Revista:
Am J Kidney Dis
Ano de publicação:
2024
Tipo de documento:
Article