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Serotonin Signaling in Hippocampus during Initial Cocaine Abstinence Drives Persistent Drug Seeking.
Kohtz, Amy S; Zhao, Joshua; Aston-Jones, Gary.
Afiliação
  • Kohtz AS; Brain Health Institute, Rutgers University, Piscataway, New Jersey 08854 akohtz@umc.edu.
  • Zhao J; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216.
  • Aston-Jones G; Brain Health Institute, Rutgers University, Piscataway, New Jersey 08854.
J Neurosci ; 44(17)2024 Apr 24.
Article em En | MEDLINE | ID: mdl-38514181
ABSTRACT
The initiation of abstinence after chronic drug self-administration is stressful. Cocaine-seeking behavior on the first day of the absence of the expected drug (Extinction Day 1, ED1) is reduced by blocking 5-HT signaling in dorsal hippocampal cornu ammonis 1 (CA1) in both male and female rats. We hypothesized that the experience of ED1 can substantially influence later relapse behavior and that dorsal raphe (DR) serotonin (5-HT) input to CA1 may be involved. We inhibited 5-HT1A/1B receptors (WAY-100635 plus GR-127935), or DR input (chemogenetics), in CA1 on ED1 to test the role of this pathway on cocaine-seeking persistence 2 weeks later. We also inhibited 5-HT1A or 5-HT1B receptors in CA1 during conditioned place preference (CPP) for cocaine, to examine mechanisms involved in the persistent effects of ED1 manipulations. Inhibition of DR inputs, or 5-HT1A/1B signaling, in CA1 decreased drug seeking on ED1 and decreased cocaine seeking 2 weeks later revealing that 5-HT signaling in CA1 during ED1 contributes to persistent drug seeking during abstinence. In addition, 5-HT1B antagonism alone transiently decreased drug-associated memory performance when given prior to a CPP test, whereas similar antagonism of 5-HT1A alone had no such effect but blocked CPP retrieval on a test 24 h later. These CPP findings are consistent with prior work showing that DR inputs to CA1 augment recall of the drug-associated context and drug seeking via 5-HT1B receptors and prevent consolidation of the updated nondrug context via 5-HT1A receptors. Thus, treatments that modulate 5-HT-dependent memory mechanisms in CA1 during initial abstinence may facilitate later maintenance of abstinence.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidiazóis / Serotonina / Cocaína / Comportamento de Procura de Droga Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidiazóis / Serotonina / Cocaína / Comportamento de Procura de Droga Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2024 Tipo de documento: Article