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Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring.
Kuzmin, Elena; Baker, Toby M; Lesluyes, Tom; Monlong, Jean; Abe, Kento T; Coelho, Paula P; Schwartz, Michael; Del Corpo, Joseph; Zou, Dongmei; Morin, Genevieve; Pacis, Alain; Yang, Yang; Martinez, Constanza; Barber, Jarrett; Kuasne, Hellen; Li, Rui; Bourgey, Mathieu; Fortier, Anne-Marie; Davison, Peter G; Omeroglu, Atilla; Guiot, Marie-Christine; Morris, Quaid; Kleinman, Claudia L; Huang, Sidong; Gingras, Anne-Claude; Ragoussis, Jiannis; Bourque, Guillaume; Van Loo, Peter; Park, Morag.
Afiliação
  • Kuzmin E; Rosalind and Morris Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address: elena.kuzmin@mcgill.ca.
  • Baker TM; The Francis Crick Institute, NW1 1AT London, UK.
  • Lesluyes T; The Francis Crick Institute, NW1 1AT London, UK.
  • Monlong J; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; McGill Genome Centre, Montreal, QC H3A 0G1, Canada.
  • Abe KT; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON M5G 1X5, Canada.
  • Coelho PP; Rosalind and Morris Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
  • Schwartz M; Rosalind and Morris Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
  • Del Corpo J; Department of Biology, Concordia University, Montreal, QC H4B 1R6, Canada.
  • Zou D; Rosalind and Morris Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada.
  • Morin G; Rosalind and Morris Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
  • Pacis A; McGill Genome Centre, Montreal, QC H3A 0G1, Canada; Canadian Centre for Computational Genomics (C3G), McGill University, Montreal, QC H3A 0G1, Canada.
  • Yang Y; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.
  • Martinez C; Rosalind and Morris Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; Department of Pathology, McGill University, Montreal, QC H3A 2B4, Canada; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H4A 3T2, Canada.
  • Barber J; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Vector Institute, Toronto, ON M5G 1M1, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Computational and Systems Biology, Sloan Kettering Institute, New York City, NY 10065, USA.
  • Kuasne H; Rosalind and Morris Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada.
  • Li R; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; McGill Genome Centre, Montreal, QC H3A 0G1, Canada.
  • Bourgey M; McGill Genome Centre, Montreal, QC H3A 0G1, Canada; Canadian Centre for Computational Genomics (C3G), McGill University, Montreal, QC H3A 0G1, Canada.
  • Fortier AM; Rosalind and Morris Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada.
  • Davison PG; Department of Surgery, McGill University, Montreal, QC H3G 1A4, Canada; McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
  • Omeroglu A; Department of Pathology, McGill University, Montreal, QC H3A 2B4, Canada.
  • Guiot MC; Department of Pathology, McGill University, Montreal, QC H3A 2B4, Canada.
  • Morris Q; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Vector Institute, Toronto, ON M5G 1M1, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Computational and Systems Biology, Sloan Kettering Institute, New York City, NY 10065, USA; Gerstne
  • Kleinman CL; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; Lady Davis Institute for Medical Research, Montreal, QC H3T 1E2, Canada.
  • Huang S; Rosalind and Morris Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.
  • Gingras AC; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON M5G 1X5, Canada.
  • Ragoussis J; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; McGill Genome Centre, Montreal, QC H3A 0G1, Canada.
  • Bourque G; Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; McGill Genome Centre, Montreal, QC H3A 0G1, Canada; Canadian Centre for Computational Genomics (C3G), McGill University, Montreal, QC H3A 0G1, Canada.
  • Van Loo P; The Francis Crick Institute, NW1 1AT London, UK; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Park M; Rosalind and Morris Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H4A 3T2, Canada. Electronic address: morag.park@mcgill.ca.
Cell Rep ; 43(4): 113988, 2024 Apr 23.
Article em En | MEDLINE | ID: mdl-38517886
ABSTRACT
The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. Analysis of The Cancer Genome Atlas data shows recurrent deletion of chr4p in basal breast cancer. Phylogenetic analysis of a panel of 23 primary tumor/patient-derived xenograft basal breast cancers reveals early evolution of chr4p deletion. Mechanistically we show that chr4p loss is associated with enhanced proliferation. Gene function studies identify an unknown gene, C4orf19, within chr4p, which suppresses proliferation when overexpressed-a member of the PDCD10-GCKIII kinase module we name PGCKA1. Genome-wide pooled overexpression screens using a barcoded library of human open reading frames identify chromosomal regions, including chr4p, that suppress proliferation when overexpressed in a context-dependent manner, implicating network interactions. Together, these results shed light on the early emergence of complex aneuploid karyotypes involving chr4p and adaptive landscapes shaping breast cancer genomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Redes Reguladoras de Genes Limite: Animals / Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2024 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Redes Reguladoras de Genes Limite: Animals / Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2024 Tipo de documento: Article