Modulating ß-catenin homeostasis for cancer therapy.
Trends Cancer
; 10(6): 507-518, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38521655
ABSTRACT
ß-Catenin is a well-established driver of many cancers; however, there are challenges in developing agents targeting ß-catenin for clinical use. Recent progress has indicated that most of the pathological changes in ß-catenin may be commonly caused by loss of protein homeostasis. Modulation of ß-catenin homeostasis, especially by hyperactivation of ß-catenin, potentially leads to robust antitumor outcomes. Here, we comprehensively dissect the protein homeostasis of ß-catenin in terms of time, compartmentalization, supramolecular assemblies, and dynamics, with emphasis on changes in ß-catenin homeostasis upon oncogenic mutations. We propose that altered ß-catenin homeostasis could be deleterious for ß-catenin-dependent cancers and that modulation of ß-catenin homeostasis offers a novel avenue for targeting ß-catenin for cancer therapy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Beta Catenina
/
Homeostase
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cancer
Ano de publicação:
2024
Tipo de documento:
Article