Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.

Anzano, M A; Roberts, A B; De Larco, J E; Wakefield, L M; Assoian, R K; Roche, N S; Smith, J M; Lazarus, J E; Sporn, M B

Anzano, M A; Roberts, A B; De Larco, J E; Wakefield, L M; Assoian, R K; Roche, N S; Smith, J M; Lazarus, J E; Sporn, M B.

Mol Cell Biol ; 5(1): 242-7, 1985 Jan.

Article em En | MEDLINE | ID: mdl-3856735

ABSTRACT

ABSTRACT

Cells transformed by Harvey or Moloney sarcoma virus secrete at least 40 times as much type beta transforming growth factor as their respective untransformed control cells. The transformed cells bind only 20 to 50% as much type beta transforming growth factor as the control cells, suggesting that transformation causes down-regulation of the type beta transforming growth factor receptor.

Assuntos

Transformação Celular Viral; Substâncias de Crescimento/metabolismo; Peptídeos/metabolismo; Bioensaio; Meios de Cultura/análise; Vírus do Sarcoma Murino de Harvey; Vírus do Sarcoma Murino de Moloney; Ensaio Radioligante; Fatores de Crescimento Transformadores

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Transformação Celular Viral / Substâncias de Crescimento Idioma: En Revista: Mol Cell Biol Ano de publicação: 1985 Tipo de documento: Article

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