Monte carlo simulation study on the dose and dose-averaged linear energy transfer distributions in carbon ion radiotherapy.
Radiol Phys Technol
; 17(2): 553-560, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38570400
ABSTRACT
Dose-averaged linear energy transfer (LETd) is conventionally evaluated from the relative biological effectiveness (RBE)-LETd fitted function used in the treatment planning system. In this study, we calculated the physical doses and their linear energy transfer (LET) distributions for patterns of typical CIRT beams using Monte Carlo (MC) simulation. The LETd was then deduced from the MC simulation and compared with that obtained from the conventional method. The two types of LETd agreed well with each other, except around the distal end of the spread-out Bragg peak. Furthermore, an MC simulation was conducted with the material composition of water and realistic materials. The profiles of physical dose and LETd were in good agreement for both techniques. These results indicate that the previous studies to analyze the minimum LETd in CIRT cases are valid for practical situations, and the material composition conversion to water little affects the dose distribution in the irradiation field.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dosagem Radioterapêutica
/
Método de Monte Carlo
/
Transferência Linear de Energia
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Radioterapia com Íons Pesados
Idioma:
En
Revista:
Radiol Phys Technol
Assunto da revista:
BIOFISICA
/
RADIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão