Chaotropic Effect-Induced Sol-Gel Transition and Radical Stabilization for Bacterially Sensitive Near-Infrared Photothermal Therapy.
Nano Lett
; 24(15): 4649-4657, 2024 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-38572971
ABSTRACT
Deep-seated bacterial infections (DBIs) are stubborn and deeply penetrate tissues. Eliminating deep-seated bacteria and promoting tissue regeneration remain great challenges. Here, a novel radical-containing hydrogel (SFT-B Gel) cross-linked by a chaotropic effect was designed for the sensing of DBIs and near-infrared photothermal therapy (NIR-II PTT). A silk fibroin solution stained with 4,4',4â³-(1,3,5-triazine-2,4,6-triyl)tris(1-methylpyridin-1-ium) (TPT3+) was employed as the backbone, which could be cross-linked by a closo-dodecaborate cluster (B12H122-) through a chaotropic effect to form the SFT-B Gel. More interestingly, the SFT-B Gel exhibited the ability to sense DBIs, which could generate a TPT2+⢠radical with obvious color changes in the presence of bacteria. The radical-containing SFT-B Gel (SFT-Bâ
Gel) possessed strong NIR-II absorption and a remarkable photothermal effect, thus demonstrating excellent NIR-II PTT antibacterial activity for the treatment of DBIs. This work provides a new approach for the construction of intelligent hydrogels with unique properties using a chaotropic effect.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fototerapia
/
Terapia Fototérmica
Idioma:
En
Revista:
Nano Lett
Ano de publicação:
2024
Tipo de documento:
Article