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Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy.
Garcia-Cordero, Indira; Anastassiadis, Chloe; Khoja, Abeer; Morales-Rivero, Alonso; Thapa, Simrika; Vasilevskaya, Anna; Davenport, Carly; Sumra, Vishaal; Couto, Blas; Multani, Namita; Taghdiri, Foad; Anor, Cassandra; Misquitta, Karen; Vandevrede, Lawren; Heuer, Hilary; Tang-Wai, David; Dickerson, Bradford; Pantelyat, Alexander; Litvan, Irene; Boeve, Bradley; Rojas, Julio C; Ljubenkov, Peter; Huey, Edward; Fox, Susan; Kovacs, Gabor G; Boxer, Adam; Lang, Anthony; Tartaglia, M Carmela.
Afiliação
  • Garcia-Cordero I; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Anastassiadis C; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Khoja A; University Health Network Memory Clinic, Toronto, ON, Canada.
  • Morales-Rivero A; Neurology Division, Medical Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Thapa S; University Health Network Memory Clinic, Toronto, ON, Canada.
  • Vasilevskaya A; ABC Medical Center, Mexico City, Mexico.
  • Davenport C; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Sumra V; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Couto B; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Multani N; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Taghdiri F; Rossy PSP Program, University Health Network and the University of Toronto, Toronto, ON, Canada.
  • Anor C; The Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto, ON, Canada.
  • Misquitta K; Institute of Cognitive and Translational Neuroscience (INCyT-INECO-CONICET), Favaloro University Hospital, Buenos Aires, Argentina.
  • Vandevrede L; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Heuer H; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Tang-Wai D; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Dickerson B; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
  • Pantelyat A; Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
  • Litvan I; Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
  • Boeve B; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
  • Rojas JC; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Ljubenkov P; Department of Neurology, John Hopkins University, Baltimore, MD, USA.
  • Huey E; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
  • Fox S; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Kovacs GG; Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
  • Boxer A; Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
  • Lang A; Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA.
  • Tartaglia MC; Rossy PSP Program, University Health Network and the University of Toronto, Toronto, ON, Canada.
Ann Neurol ; 96(1): 99-109, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38578117
ABSTRACT

OBJECTIVES:

To evaluate the effect of Alzheimer's disease (AD) -related biomarker change on clinical features, brain atrophy and functional connectivity of patients with corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP).

METHODS:

Data from patients with a clinical diagnosis of CBS, PSP, and AD and healthy controls were obtained from the 4-R-Tauopathy Neuroimaging Initiative 1 and 2, the Alzheimer's Disease Neuroimaging Initiative, and a local cohort from the Toronto Western Hospital. Patients with CBS and PSP were divided into AD-positive (CBS/PSP-AD) and AD-negative (CBS/PSP-noAD) groups based on fluid biomarkers and amyloid PET scans. Cognitive, motor, and depression scores; AD fluid biomarkers (cerebrospinal p-tau, t-tau, and amyloid-beta, and plasma ptau-217); and neuroimaging data (amyloid PET, MRI and fMRI) were collected. Clinical features, whole-brain gray matter volume and functional networks connectivity were compared across groups.

RESULTS:

Data were analyzed from 87 CBS/PSP-noAD and 23 CBS/PSP-AD, 18 AD, and 30 healthy controls. CBS/PSP-noAD showed worse performance in comparison to CBS/PSP-AD in the PSPRS [mean(SD) 34.8(15.8) vs 23.3(11.6)] and the UPDRS scores [mean(SD) 34.2(17.0) vs 21.8(13.3)]. CBS/PSP-AD demonstrated atrophy in AD signature areas and brainstem, while CBS/PSP-noAD patients displayed atrophy in frontal and temporal areas, globus pallidus, and brainstem compared to healthy controls. The default mode network showed greatest disconnection in CBS/PSP-AD compared with CBS/PSP-no AD and controls. The thalamic network connectivity was most affected in CBS/PSP-noAD.

INTERPRETATION:

AD biomarker positivity may modulate the clinical presentation of CBS/PSP, with evidence of distinctive structural and functional brain changes associated with the AD pathology/co-pathology. ANN NEUROL 2024;9699-109.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paralisia Supranuclear Progressiva / Biomarcadores / Doença de Alzheimer Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paralisia Supranuclear Progressiva / Biomarcadores / Doença de Alzheimer Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Canadá