Adaptive platform trials rather than randomised controlled trials for paediatric sepsis.
Emerg Med Australas
; 36(3): 488-490, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38600436
ABSTRACT
Adaptive platform trials (APTs) offer a promising alternative to traditional randomised controlled trials for evaluating treatments for paediatric sepsis. Randomised controlled trials, despite being the gold standard for establishing causality between interventions and outcomes, make many assumptions about disease prevalence, severity and intervention effects, which are often incorrect. As a result, the evidence for most treatments for paediatric sepsis are based on low-quality evidence. APTs use accrued data rather than assumptions to power trial adaptations. They can assess multiple treatments simultaneously with shared research infrastructure. As such, APTs offer a more efficient, flexible and more effective way to identify optimal treatments. The proposed Paediatric Adaptive Sepsis Platform Trial, leveraging the Paediatric Research in Emergency Departments International Collaborative network's infrastructure, will evaluate resuscitation fluids, vasoactive medications, corticosteroids and antimicrobials. This trial has the potential to substantially impact clinical practice and reduce global sepsis mortality in children.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Sepse
Limite:
Child
/
Humans
Idioma:
En
Revista:
Emerg Med Australas
Assunto da revista:
MEDICINA DE EMERGENCIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Austrália