Complement-mediated thrombotic microangiopathy on a background of Alport syndrome: A case report.

Coorey, Craig Peter; de Malmanche, Theo; Chou, Angela; Feddersen, Martin

Coorey, Craig Peter; de Malmanche, Theo; Chou, Angela; Feddersen, Martin.

Afiliação

Coorey CP; Renal Unit, Gosford Hospital, Gosford, New South Wales, Australia.
de Malmanche T; School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia.
Chou A; Immunology, NSW Health Pathology, Newcastle, New South Wales, Australia.
Feddersen M; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.

Nephrology (Carlton) ; 29(10): 688-690, 2024 Oct.

Article em En | MEDLINE | ID: mdl-38604610

ABSTRACT

ABSTRACT

Here we present a case of complement-mediated thrombotic microangiopathy (TMA) in a patient who has a background of Stage 5 chronic kidney disease secondary to Alport syndrome. We explain our approach to the diagnosis of TMA, especially the reliance on non-renal manifestations of TMA and the role of kidney biopsy given there was a background of advanced kidney impairment at baseline.

Assuntos

Nefrite Hereditária; Microangiopatias Trombóticas; Humanos; Nefrite Hereditária/complicações; Nefrite Hereditária/diagnóstico; Microangiopatias Trombóticas/etiologia; Microangiopatias Trombóticas/diagnóstico; Biópsia; Masculino; Rim/patologia; Adulto; Ativação do Complemento; Resultado do Tratamento

Palavras-chave

Alport syndrome (hereditary nephritis); acute kidney injury; thrombotic microangiopathy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microangiopatias Trombóticas / Nefrite Hereditária Limite: Adult / Humans / Male Idioma: En Revista: Nephrology (Carlton) Assunto da revista: NEFROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália

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