Hazard function analysis of prognosis after recurrent colorectal cancer.
Langenbecks Arch Surg
; 409(1): 123, 2024 Apr 13.
Article
em En
| MEDLINE
| ID: mdl-38613567
ABSTRACT
BACKGROUND AND OBJECTIVES:
Mean survival time (MST) is used as the indicator of prognosis in patients with a colorectal cancer (CRC) recurrence. The present study aimed to visualize the changes in death risk after a CRC recurrence using hazard function analysis (HFA) to provide an alternative prognostic indicator to MST.METHODS:
The medical records of 725 consecutive patients with a recurrence following R0 radical surgery for CRC were retrospectively reviewed.RESULTS:
The five-year, post-recurrence survival rate was 37.8%, and the MST was 3.5 years while the risk of death peaked at 2.9 years post-recurrence. Seven variables were found to predict short-term survival, including the number of metastatic organs ≥ 2, non-surgical treatment for the recurrence, and a short interval before recurrence. In patients with a recurrence in one organ, the MST was four years, the peak time of death predicted by HFA was 2.9 years, and the five-year survival rate was 45.8%. In patients with a surgical resection of the recurrence, the MST was 8 years, the peak time of death was 3.3 years, and the five-year survival rate was 62%.CONCLUSIONS:
The present study established a novel method of assessing changes in mortality risk over time using HFA in patients with a CRC recurrence.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
Limite:
Humans
Idioma:
En
Revista:
Langenbecks Arch Surg
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão