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Utility of human epidermal growth factor 2 heterogeneity as a prognostic factor in triple-negative breast cancer.
Narusawa, Eriko; Kurozumi, Sasagu; Katayama, Ayaka; Koibuchi, Yukio; Ogawa, Akira; Takata, Daisuke; Tokuda, Shoko; Obayashi, Sayaka; Oyama, Tetsunari; Horiguchi, Jun; Shirabe, Ken; Fujii, Takaaki.
Afiliação
  • Narusawa E; Department of Breast and Endocrine Surgery, National Hospital Organization Takasaki General Medical Center, Gunma, Japan.
  • Kurozumi S; Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Katayama A; Department of Breast and Endocrine Surgery, National Hospital Organization Takasaki General Medical Center, Gunma, Japan. skurozumi@iuhw.ac.jp.
  • Koibuchi Y; Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma, Japan. skurozumi@iuhw.ac.jp.
  • Ogawa A; Department of Breast Surgery, International University of Health and Welfare, 852, Hatakeda, Narita City, Chiba, 286-8520, Japan. skurozumi@iuhw.ac.jp.
  • Takata D; Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Tokuda S; Department of Breast and Endocrine Surgery, National Hospital Organization Takasaki General Medical Center, Gunma, Japan.
  • Obayashi S; Department of Diagnostic Pathology, National Hospital Organization Takasaki General Medical Center, Gunma, Japan.
  • Oyama T; Department of Breast and Endocrine Surgery, National Hospital Organization Takasaki General Medical Center, Gunma, Japan.
  • Horiguchi J; Department of Breast and Endocrine Surgery, National Hospital Organization Takasaki General Medical Center, Gunma, Japan.
  • Shirabe K; Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma, Japan.
  • Fujii T; Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Gunma, Japan.
Med Mol Morphol ; 57(3): 177-184, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38619618
ABSTRACT
In some cases of human epidermal growth factor 2 (HER2)-negative breast cancer, including triple-negative breast cancer, HER2 expression is sporadically and strongly upregulated, a condition known as HER2 heterogeneity. We investigated the clinicopathological features of patients with HER2 heterogeneity in triple-negative breast cancers treated with neoadjuvant chemotherapy. Thirty-nine patients with triple-negative breast cancer who had undergone preoperative chemotherapy participated in this study. To assess for HER2 heterogeneity, we used dual in situ hybridization slides. We evaluated the association between HER2 heterogeneity and clinicopathological factors such as rates of pathologic complete response (pCR) and of recurrence-free survival. Of the 39 patients, 15 (38.5%) had cancers with HER2 heterogeneity. The pCR rates were 13.3% among patients with HER2 heterogeneity and 20.8% among those with HER2 nonheterogeneity, but the difference was not significant. The recurrence-free survival rate was significantly lower in patients with HER2 heterogeneity than in those without (P = 0.025). HER2 heterogeneity is a significant predictor of poor prognosis in patients with triple-negative breast cancer treated with neoadjuvant chemotherapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor ErbB-2 / Terapia Neoadjuvante / Neoplasias de Mama Triplo Negativas Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Med Mol Morphol Assunto da revista: BIOLOGIA MOLECULAR / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor ErbB-2 / Terapia Neoadjuvante / Neoplasias de Mama Triplo Negativas Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Med Mol Morphol Assunto da revista: BIOLOGIA MOLECULAR / PATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão