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Dihydrostilbenes from Macaranga javanica (Blume) Müll. Arg. and their antiplasmodial activity.
Tjahjandarie, Tjitjik Srie; Aldin, Muhammad Fajar; Saputri, Ratih Dewi; Tanjung, Mulyadi.
Afiliação
  • Tjahjandarie TS; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Aldin MF; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Saputri RD; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia.
  • Tanjung M; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Nat Prod Res ; : 1-7, 2024 Apr 17.
Article em En | MEDLINE | ID: mdl-38629185
ABSTRACT
An undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC50 value of 0.85 and 1.03 µg/mL, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Prod Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Indonésia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Prod Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Indonésia