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Enteropathy and intestinal malabsorption in patients treated with antihypertensive drugs. A retrospective cohort study.
Lee, Sae R; Lee, Eun G; Cho, Young H; Park, Eun J; Lee, Young-In; Choi, Jung I; Kwon, Ryuk-Jun; Son, Soo M; Lee, Sang Y; Yi, Yu H; Kim, Gyu L; Kim, Yun J; Lee, Jeong G; Tak, Young Jin; Lee, Seung Hun; Ra, Young Jin.
Afiliação
  • Lee SR; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Lee EG; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Cho YH; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Park EJ; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Lee YI; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Choi JI; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Kwon RJ; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Son SM; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Lee SY; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Yi YH; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Kim GL; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Kim YJ; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Lee JG; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Tak YJ; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Lee SH; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
  • Ra YJ; From the Department of Family Medicine and Biomedical Research Institute (S. R. Lee, E. G. Lee, Y. H. Cho, E. J. Park, Y. Lee, J. I. Choi, R. Kwon, S. M. Son, S. Y. Lee); from the Department of Family Medicine (G. L. Kim, S. H. Lee, Y. J. Ra), Pusan National University Yangsan Hospital, from the Dep
Saudi Med J ; 45(4): 437-441, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38657980
ABSTRACT

OBJECTIVES:

To investigate differences in the incidence of enteropathy or intestinal malabsorption in patients taking angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitor (ACEI), calcium channel blocker (CCB), and beta blockers (BBs) at a single center in Korea.

METHODS:

In this retrospective study, we utilized data from the Yangsan electronic medical records to identify 129,169 patients. These individuals were prescribed olmesartan, other ARBs, ACEI, CCB, and BBs between November 2008 and February 2021.

RESULTS:

Of the 44,775 patients, 51 (0.11%) were observed to have enteropathy or intestinal malabsorption. Compared with the ACEI group, the adjusted odds ratios (ORs) for enteropathy and intestinal malabsorption were OR=1.313 (95% confidence interval [CI] [0.188-6.798], p=0.893) for olmesartan, OR=0.915 (95% CI [0.525-1.595], p=0.754) for the other ARBs, OR=0.928 (95% CI [0.200-4.307]; p=0.924) for the CCB, and OR=0.663 (95% CI [0.151-2.906]; p=0.586) for the BBs group. These findings were adjusted for factors such as age, gender, duration of antihypertensive medication, and comorbidities.

CONCLUSION:

In a retrospective cohort study of patients on antihypertensive medications, no significant difference was found in the incidence of enteropathy or intestinal malabsorption when ACEI was compared to olmesartan, other ARBs, CCB, and BBs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Enzima Conversora de Angiotensina / Bloqueadores dos Canais de Cálcio / Antagonistas de Receptores de Angiotensina / Síndromes de Malabsorção / Anti-Hipertensivos Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Saudi Med J Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Enzima Conversora de Angiotensina / Bloqueadores dos Canais de Cálcio / Antagonistas de Receptores de Angiotensina / Síndromes de Malabsorção / Anti-Hipertensivos Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Saudi Med J Ano de publicação: 2024 Tipo de documento: Article