Cerebellar Functions Beyond Movement and Learning.
Annu Rev Neurosci
; 47(1): 145-166, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38663092
ABSTRACT
The cerebellum has a well-established role in controlling motor functions, including coordination, posture, and the learning of skilled movements. The mechanisms for how it carries out motor behavior remain under intense investigation. Interestingly though, in recent years the mechanisms of cerebellar function have faced additional scrutiny since nonmotor behaviors may also be controlled by the cerebellum. With such complexity arising, there is now a pressing need to better understand how cerebellar structure, function, and behavior intersect to influence behaviors that are dynamically called upon as an animal experiences its environment. Here, we discuss recent experimental work that frames possible neural mechanisms for how the cerebellum shapes disparate behaviors and why its dysfunction is catastrophic in hereditary and acquired conditions-both motor and nonmotor. For these reasons, the cerebellum might be the ideal therapeutic target.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cerebelo
/
Aprendizagem
/
Movimento
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Neurosci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos