Ring finger protein 138 inhibits transcription factor C/EBP&#945; protein turnover leading to differentiation arrest in acute myeloid leukemia.

Singh, Anil Kumar; Upadhyay, Vishal; Sethi, Arppita; Chowdhury, Sangita; Mishra, Shivkant; Verma, Shailendra Prasad; Bhatt, Madan Lal Brahma; Trivedi, Arun Kumar

Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia.

Singh, Anil Kumar; Upadhyay, Vishal; Sethi, Arppita; Chowdhury, Sangita; Mishra, Shivkant; Verma, Shailendra Prasad; Bhatt, Madan Lal Brahma; Trivedi, Arun Kumar.

Afiliação

Singh AK; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India.
Upadhyay V; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Sethi A; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India.
Chowdhury S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Mishra S; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India.
Verma SP; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Bhatt MLB; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India.
Trivedi AK; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, UP, India.

Biochem J ; 481(10): 653-666, 2024 May 22.

Article em En | MEDLINE | ID: mdl-38666590

Assuntos

Proteína alfa Estimuladora de Ligação a CCAAT; Diferenciação Celular; Leucemia Mieloide Aguda; Ubiquitina-Proteína Ligases; Humanos; Proteína alfa Estimuladora de Ligação a CCAAT/metabolismo; Proteína alfa Estimuladora de Ligação a CCAAT/genética; Proteínas Estimuladoras de Ligação a CCAAT; Diferenciação Celular/genética; Células HEK293; Células HL-60; Leucemia Mieloide Aguda/metabolismo; Leucemia Mieloide Aguda/genética; Leucemia Mieloide Aguda/patologia; Proteólise; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo

Palavras-chave

C/EBPα; RNF138; acute myeloid leukaemia; differentiation; ubiquitin ligases; ubiquitination

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Diferenciação Celular / Proteína alfa Estimuladora de Ligação a CCAAT / Ubiquitina-Proteína Ligases Limite: Humans Idioma: En Revista: Biochem J Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia

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