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Quality of life in chordoma survivors: results from the Chordoma Foundation Survivorship Survey.
Jimenez, Adrian E; Cicalese, Kyle V; Jimenez, Miguel A; Chakravarti, Sachiv; Kuo, Cathleen C; Lozinsky, Shannon; Schwab, Joseph H; Knowlton, Sasha E; Rowan, Nicholas R; Mukherjee, Debraj.
Afiliação
  • Jimenez AE; 1Department of Neurosurgery, Columbia University Medical Center, New York, New York.
  • Cicalese KV; 2Department of Neurosurgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
  • Jimenez MA; 3Department of Neurosurgery, The University of Chicago Pritzker School of Medicine, Chicago, Illinois.
  • Chakravarti S; Departments of4Neurosurgery and.
  • Kuo CC; 5Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo, New York.
  • Lozinsky S; 6Chordoma Foundation, Durham, North Carolina.
  • Schwab JH; 7Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and.
  • Knowlton SE; 8Department of Physical Medicine and Rehabilitation, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
  • Rowan NR; 9Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Mukherjee D; Departments of4Neurosurgery and.
Neurosurg Focus ; 56(5): E12, 2024 05.
Article em En | MEDLINE | ID: mdl-38691854
ABSTRACT

OBJECTIVE:

Chordomas are rare malignant bone tumors whose location in the skull base or spine, invasive surgical treatment, and accompanying adjuvant radiotherapy may all lead patients to experience poor quality of life (QOL). Limited research has been conducted on specific demographic and clinical factors associated with decreased QOL in chordoma survivors. Thus, the aim of the present study was to investigate several potential variables and their impact on specific QOL domains in these patients as well the frequencies of specific QOL challenges within these domains.

METHODS:

The Chordoma Foundation (CF) Survivorship Survey was electronically distributed to chordoma survivors subscribed to the CF Chordoma Connections forum. Survey questions assessed QOL in three domains physical, emotional/cognitive, and social. The degree of impairment was assessed by grouping the participants into high- and low-challenge groups designated by having ≥ 5 or < 5 symptoms or challenges within a given QOL domain. Bivariate analysis of demographic and clinical characteristics between these groups was conducted using Fisher's exact test and the Mann-Whitney U-test.

RESULTS:

A total of 665 chordoma survivors at least partially completed the survey. On bivariate analysis, female sex was significantly associated with increased odds of significant emotional (p = 0.001) and social (p = 0.019) QOL burden. Younger survivors (age < 65 years) were significantly more likely to experience significant physical (p < 0.0001), emotional (p < 0.0001), and social (p < 0.0001) QOL burden. Skull base chordoma survivors had significantly higher emotional/cognitive QOL burden than spinal chordoma survivors (p = 0.022), while the converse was true for social QOL challenges (p = 0.0048). Survivors currently in treatment were significantly more likely to experience significant physical QOL challenges compared with survivors who completed their treatment > 10 years ago (p = 0.0074). Fear of cancer recurrence (FCR) was the most commonly reported emotional/cognitive QOL challenge (49.6%). Only 41% of the participants reported having their needs met for their physical QOL challenges as well as 25% for emotional/cognitive and 18% for social.

CONCLUSIONS:

The authors' findings suggest that younger survivors, female survivors, and survivors currently undergoing treatment for chordoma are at high risk for adverse QOL outcomes. Additionally, although nearly half of the participants reported a FCR, very few reported having adequate emotional/cognitive care. These findings may be useful in identifying specific groups of chordoma survivors vulnerable to QOL challenges and bring to light the need to expand care to meet the QOL needs for these patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Cordoma Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurosurg Focus Assunto da revista: NEUROCIRURGIA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Cordoma Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurosurg Focus Assunto da revista: NEUROCIRURGIA Ano de publicação: 2024 Tipo de documento: Article