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A novel animal model for understanding secondary traumatic stress and visceral pain in male rats.
Lannon, Adam S; Brocka, Marta; Collins, James M; Fitzgerald, Patrick; O'Mahony, Siobhain M; Cryan, John F; Moloney, Rachel D.
Afiliação
  • Lannon AS; School of Pharmacy, University College Cork, Ireland.
  • Brocka M; Department of Pharmacology and Therapeutics, University College Cork, Ireland.
  • Collins JM; APC Microbiome Ireland, University College Cork, Ireland.
  • Fitzgerald P; APC Microbiome Ireland, University College Cork, Ireland.
  • O'Mahony SM; Department of Anatomy and Neuroscience, University College Cork, Ireland.
  • Cryan JF; APC Microbiome Ireland, University College Cork, Ireland.
  • Moloney RD; Department of Anatomy and Neuroscience, University College Cork, Ireland.
Eur J Neurosci ; 60(1): 3544-3556, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38695253
ABSTRACT
Empathetic relationships and the social transference of behaviours have been shown to occur in humans, and more recently through the development of rodent models, where both fear and pain phenotypes develop in observer animals. Clinically, observing traumatic events can induce 'trauma and stressor-related disorders' as defined in the DSM 5. These disorders are often comorbid with pain and gastrointestinal disturbances; however, our understanding of how gastrointestinal - or visceral - pain can be vicariously transmitted is lacking. Visceral pain originates from the internal organs, and despite its widespread prevalence, remains poorly understood. We established an observation paradigm to assess the impact of witnessing visceral pain. We utilised colorectal distension (CRD) to induce visceral pain behaviours in a stimulus rodent while the observer rodent observed. Twenty four hours post-observation, the observer rodent's visceral sensitivity was assessed using CRD. The observer rodents were found to have significant hyperalgesia as determined by lower visceral pain threshold and higher number of total pain behaviours compared with controls. The behaviours of the observer animals during the observation were found to be correlated with the behaviours of the stimulus animal employed. We found that observer animals had hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis, highlighted by reduced corticosterone at 90 minutes post-CRD. Using c-Fos immunohistochemistry we showed that observer animals also had increased activation of the anterior cingulate cortex, and decreased activation of the paraventricular nucleus, compared with controls. These results suggest that witnessing another animal in pain produces a behavioural phenotype and impacts the brain-gut axis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Psicológico / Modelos Animais de Doenças / Dor Visceral Limite: Animals Idioma: En Revista: Eur J Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Irlanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Psicológico / Modelos Animais de Doenças / Dor Visceral Limite: Animals Idioma: En Revista: Eur J Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Irlanda