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Clinical Use of Super-Bioavailable Itraconazole for the Management of Dermatophytosis: Consensus Statement by Dermatologists from India via the Modified Delphi Technique.
Saraswat, Abir; Dogra, Sunil; Shenoy, Manjunath; Verma, Shyam; K, Seetharam; Ghate, Sunil; Ganjoo, Anil; Aurangabadkar, Sanjeev; Tiwari, Anurag; Poojary, Shital; Inamdar, Arun; Majid, Imran; Girdhar, Mukesh; Shah, Bela; Varma, Sachin; Ramamoorthy, Ramkumar; Dhoot, Dhiraj; Barkate, Hanmant.
Afiliação
  • Saraswat A; Department of Dermatology, Indushree Skin Clinic, Lucknow, India.
  • Dogra S; Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Shenoy M; Department of Dermatology, Yenepoya Medical College, Mangalore, India.
  • Verma S; Department of Dermatology, Nirvan Skin Clinic, Vadodara, India.
  • K S; Department of Dermatology, GSL Medical College, Rajamundry, India.
  • Ghate S; Department of Dermatology, Dr Ghate's Skin, Hair and LASER Centre, Mumbai, India.
  • Ganjoo A; Department of Dermatology, Skinnovation Clinics, New Delhi, India.
  • Aurangabadkar S; Department of Dermatology, Dr. Aurangabadkar's Skin and Laser Clinics, Hyderabad, India.
  • Tiwari A; Department of Dermatology, Center for Skin Diseases and Laser Treatment, Bhopal, India.
  • Poojary S; Department of Dermatology, K J Somaiya Medical College, Mumbai, India.
  • Inamdar A; Department of Dermatology, Sri B M Patil Medical College, BLDE Deemed University, Vijayapur, India.
  • Majid I; Department of Dermatology, Cutis Institute of Dermatology, Srinagar, India.
  • Girdhar M; Department of Dermatology, Max Super Specialty Hospital, Ppg, Delhi, India.
  • Shah B; Department of Dermatology, BJ Medical College and Civil Hospital, Ahmedabad, India.
  • Varma S; Department of Dermatology, Skinvita Clinic, Kolkata, India.
  • Ramamoorthy R; Department of Dermatology, Kanchi Kamakotichild Trust Hospital, Chennai, India.
  • Dhoot D; Department of Global Medical Affairs, Glenmark Pharmaceuticals Ltd., Mumbai, India.
  • Barkate H; Department of Global Medical Affairs, Glenmark Pharmaceuticals Ltd., Mumbai, India.
Dermatology ; 240(4): 671-683, 2024.
Article em En | MEDLINE | ID: mdl-38697027
ABSTRACT
Super-bioavailable itraconazole (SB ITZ) overcomes the limitations of conventional itraconazole (CITZ) such as interindividual variability and reduced bioavailability. It has been approved for systemic mycoses in Australia and Europe as 50 mg and the USA as 65 mg and in India as 50 mg, 65 mg, 100 mg, and 130 mg. However, data on the ideal dose and duration of SB ITZ treatment in managing dermatophytosis are insufficient. This consensus discusses the suitability, dosage, duration of treatment, and relevance of using SB ITZ in managing dermatophytosis in different clinical scenarios. Sixteen dermatologists (>15 years of experience in the field and ≥2 years clinical experience with SB ITZ), formed the expert panel. A modified Delphi technique was employed, and a consensus was reached if the concordance in response was >75%. A total of 26 consensus statements were developed. The preferred dose of SB ITZ is 130 mg once daily and if not tolerated, 65 mg twice daily. The preferred duration for treating naïve dermatophytosis is 4-6 weeks and that for recalcitrant dermatophytosis is 6-8 weeks. Moreover, cure rates for dermatophytosis are a little better with SB ITZ than with CITZ with a similar safety profile as of CITZ. Better patient compliance and efficacy are associated with SB ITZ than with CITZ, even in patients with comorbidities and special needs such as patients with diabetes, extensive lesions, corticosteroid abuse, adolescents, and those on multiple drugs. Expert clinicians reported that the overall clinical experience with SB ITZ was better than that with CITZ.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tinha / Técnica Delphi / Itraconazol / Consenso / Antifúngicos Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Dermatology Assunto da revista: DERMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tinha / Técnica Delphi / Itraconazol / Consenso / Antifúngicos Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Dermatology Assunto da revista: DERMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia