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Drug Concentrations in Hair and Dried Blood Spots as Preexposure Prophylaxis Adherence Metrics During Pregnancy and Postpartum.
Wu, Linxuan; Kinuthia, John; Anderson, Peter L; Baeten, Jared M; Dettinger, Julia C; Gandhi, Monica; Gomez, Laurén; John-Stewart, Grace; Marwa, Mary M; Ngumbau, Nancy; Otieno, Felix; Omondi, Pascal; Odhiambo, Ben; Watoyi, Salphine; Pintye, Jillian.
Afiliação
  • Wu L; Department of Epidemiology, University of Washington, Seattle.
  • Kinuthia J; Department of Global Health, University of Washington, Seattle.
  • Anderson PL; Department of Global Health, University of Washington, Seattle.
  • Baeten JM; Department of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
  • Dettinger JC; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora.
  • Gandhi M; Department of Epidemiology, University of Washington, Seattle.
  • Gomez L; Department of Global Health, University of Washington, Seattle.
  • John-Stewart G; Department of Medicine, University of Washington, Seattle.
  • Marwa MM; Department of Global Health, University of Washington, Seattle.
  • Ngumbau N; Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco.
  • Otieno F; Department of Epidemiology, University of Washington, Seattle.
  • Omondi P; Department of Global Health, University of Washington, Seattle.
  • Odhiambo B; Department of Epidemiology, University of Washington, Seattle.
  • Watoyi S; Department of Global Health, University of Washington, Seattle.
  • Pintye J; Department of Medicine, University of Washington, Seattle.
J Infect Dis ; 230(3): 689-695, 2024 Sep 23.
Article em En | MEDLINE | ID: mdl-38700101
ABSTRACT
We evaluated hair tenofovir (TFV) concentrations as an adherence metric for HIV preexposure prophylaxis during pregnancy and postpartum and compared hair levels with TFV-diphosphate levels in dried blood spots (DBSs). Overall 152 hair samples from 102 women and 36 hair-DBS paired samples from 29 women were collected from a subset of women in a cluster-randomized trial. Having a partner with HIV was associated with higher hair TFV levels (P < .001). Hair TFV concentrations were strongly correlated with DBS TFV-diphosphate levels (r = 0.76, P < .001), indicating hair as a promising cumulative adherence metric for perinatal preexposure prophylaxis assessment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Infect Dis Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Infect Dis Ano de publicação: 2024 Tipo de documento: Article