Changes in the hippocampal level of tau but not beta-amyloid may mediate anxiety-like behavior improvement ensuing from exercise in diabetic female rats.
Behav Brain Funct
; 20(1): 9, 2024 May 03.
Article
em En
| MEDLINE
| ID: mdl-38702776
ABSTRACT
BACKGROUND:
In the present study, we investigated the effect of high-intensity interval training (HIIT) on cognitive behaviors in female rats with a high-fat diet + streptozotocin (STZ)-induced type 2 diabetes.METHODS:
Twenty-four female rats were divided into four groups randomly (n = 6) control (C), control + exercise (Co + EX), diabetes mellitus (type 2) (T2D), and diabetes mellitus + exercise (T2D + EX). Diabetes was induced by a two-month high-fat diet and a single dose of STZ (35 mg/kg) in the T2D and T2D + EX groups. The Co + EX and T2D + EX groups performed HIIT for eight weeks (five sessions per week, running on a treadmill at 80-100% of VMax, 4-10 intervals). Elevated plus maze (EPM) and open field test (OFT) were used for assessing anxiety-like behaviors, and passive avoidance test (PAT) and Morris water maze (MWM) were applied for evaluating learning and memory. The hippocampal levels of beta-amyloid (Aß) and Tau were also assessed using Western blot.RESULTS:
An increase in fasting blood glucose (FBG), hippocampal level of Tau, and a decrease in the percentage of open arm time (%OAT) as an index of anxiety-like behavior were seen in the female diabetic rats which could be reversed by HIIT. In addition, T2D led to a significant decrease in rearing and grooming in the OFT. No significant difference among groups was seen for the latency time in the PAT and learning and memory in the MWM.CONCLUSIONS:
HIIT could improve anxiety-like behavior at least in part through changes in hippocampal levels of Tau.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiedade
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Condicionamento Físico Animal
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Peptídeos beta-Amiloides
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Proteínas tau
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Diabetes Mellitus Experimental
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Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Behav Brain Funct
Assunto da revista:
CEREBRO
/
CIENCIAS DO COMPORTAMENTO
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Irã