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Physiological and pathological functions of TMEM106B in neurodegenerative diseases.
Zhu, Min; Zhang, Guoxin; Meng, Lanxia; Xiao, Tingting; Fang, Xin; Zhang, Zhentao.
Afiliação
  • Zhu M; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
  • Zhang G; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
  • Meng L; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
  • Xiao T; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
  • Fang X; Department of Neurology, the First Affiliated Hospital of Nanchang University, Nanchang, 330000, China. fangx2011@163.com.
  • Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. zhentaozhang@whu.edu.cn.
Cell Mol Life Sci ; 81(1): 209, 2024 May 06.
Article em En | MEDLINE | ID: mdl-38710967
ABSTRACT
As an integral lysosomal transmembrane protein, transmembrane protein 106B (TMEM106B) regulates several aspects of lysosomal function and is associated with neurodegenerative diseases. The TMEM106B gene mutations lead to lysosomal dysfunction and accelerate the pathological progression of Neurodegenerative diseases. Yet, the precise mechanism of TMEM106B in Neurodegenerative diseases remains unclear. Recently, different research teams discovered that TMEM106B is an amyloid protein and the C-terminal domain of TMEM106B forms amyloid fibrils in various Neurodegenerative diseases and normally elderly individuals. In this review, we discussed the physiological functions of TMEM106B. We also included TMEM106B gene mutations that cause neurodegenerative diseases. Finally, we summarized the identification and cryo-electronic microscopic structure of TMEM106B fibrils, and discussed the promising therapeutic strategies aimed at TMEM106B fibrils and the future directions for TMEM106B research in neurodegenerative diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Proteínas de Membrana / Proteínas do Tecido Nervoso Limite: Animals / Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Proteínas de Membrana / Proteínas do Tecido Nervoso Limite: Animals / Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China