A Pharmacological perspective on the temporal properties of sweeteners.
Pharmacol Res
; 204: 107211, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38744400
ABSTRACT
Several non-caloric sweeteners exhibit a delay in sweetness onset and a sweetness linger after sampling. These temporal properties are thought to be the result of non-specific interactions with cell membranes and proteins in the oral cavity. Data and analysis presented in this report also support the potential involvement of receptor affinity and binding kinetics to this phenomenon. In general, affected sweeteners exhibit distinctly higher binding affinity compared to carbohydrate sweeteners, which do not have temporal issues. In addition, binding kinetic simulations illustrate much slower receptor binding association and dissociation kinetics for a set of non-caloric sweeteners presenting temporal issues, in comparison to carbohydrate sweeteners. So, the higher affinity of some non-caloric sweeteners, dictating lower use levels, and affecting binding kinetics, could contribute to their delay and linger in sweetness perception. Simple pharmacology principles could explain, at least in part, some of the temporal issues of sweeteners.
Palavras-chave
Advantame (PubChem CID: 56843846); Aspartame (PubChem CID: 134601); Glyccyrhizin (PubChem CID: 14982); Mogroside V (PubChem CID: 24721270); Neohesperidin dihydrochalcone (PubChem CID: 30231); Neotame (PubChem CID: 9810996); Phyllodulcin (PubChem CID: 146694); SC-45647 (PubChem CID: 13960828); Sucralose (PubChem CID: 71485); Sucrose (PubChem CID: 5988); Taste receptors; binding; off-rate; on-rate; sweeteners; temporal; time intensity
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Edulcorantes
/
Percepção Gustatória
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Res
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article