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Concepts of lines of therapy in cancer treatment: findings from an expert interview-based study.
Falchetto, Lisa; Bender, Bernd; Erhard, Ian; Zeiner, Kim N; Stratmann, Jan A; Koll, Florestan J; Wagner, Sebastian; Reiser, Marcel; Gasimli, Khayal; Stehle, Angelika; Voss, Martin; Ballo, Olivier; Vehreschild, Jörg Janne; Maier, Daniel.
Afiliação
  • Falchetto L; Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Faculty of Medicine, Frankfurt, Germany.
  • Bender B; Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Faculty of Medicine, Frankfurt, Germany. B.Bender@med.uni-frankfurt.de.
  • Erhard I; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany. B.Bender@med.uni-frankfurt.de.
  • Zeiner KN; Institute for Digital Medicine and Clinical Data Science, Goethe University Frankfurt, Faculty of Medicine, Frankfurt, Germany.
  • Stratmann JA; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Koll FJ; Department for Dermatology, Venerology and Allergology, University Hospital Frankfurt, Frankfurt, Germany.
  • Wagner S; Medical Department 2 (Hematology/Oncology), Center for Internal Medicine, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.
  • Reiser M; Department of Urology, University Hospital Frankfurt, Frankfurt, Germany.
  • Gasimli K; Medical Department 2 (Hematology/Oncology), Center for Internal Medicine, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.
  • Stehle A; PIOH Praxis Internistischer Onkologie und Hämatologie, Cologne, Germany.
  • Voss M; Clinic for Gynecology and Obstetrics, University Hospital Frankfurt, Frankfurt, Germany.
  • Ballo O; Department for Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany.
  • Vehreschild JJ; Department Neuro-Oncology, University Hospital Frankfurt, Frankfurt, Germany.
  • Maier D; Medical Department 2 (Hematology/Oncology), Center for Internal Medicine, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.
BMC Res Notes ; 17(1): 137, 2024 May 15.
Article em En | MEDLINE | ID: mdl-38750530
ABSTRACT

OBJECTIVE:

The concept of lines of therapy (LOT) in cancer treatment is often considered for decision making in tumor boards and clinical management, but lacks a common definition across medical specialties. The complexity and heterogeneity of malignancies and treatment modalities contribute to an inconsistent understanding of LOT among physicians. This study assesses the heterogeneity of understandings of the LOT concept, its major dimensions, and criteria from the perspective of physicians of different specialties with an oncological focus in Germany. Semi-structured expert interviews with nine physicians were conducted and evaluated using qualitative content analysis.

RESULTS:

Most interviewees agreed that there is no single definition for LOT and found it difficult to explicate their understanding. A majority of experts stated that they had already encountered misunderstandings with colleagues regarding LOT and that they had problems with deciphering LOT from the medical records of their patients. Disagreement emerged about the roles of the following within the LOT concept maintenance therapy, treatment intention, different therapy modalities, changing pharmaceutical agents, and therapy breaks. Respondents predominantly considered the same criteria as decisive for the definition of LOT as for a change in LOT (e.g., the occurrence of a progression event or tumor recurrence).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: BMC Res Notes Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: BMC Res Notes Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Alemanha