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New Insights into the Role of Mild Hypoxia in Regulating Neural Stem Cell Characteristics.
Guo, Jian-Jun; Su, Rui-Bin; Wu, Hai-Tao; Zhu, Ling-Ling.
Afiliação
  • Guo JJ; Beijing Institute of Basic Medical Sciences, Beijing, People's Republic of China.
  • Su RB; Beijing Institute of Basic Medical Sciences, Beijing, People's Republic of China.
  • Wu HT; Beijing Institute of Basic Medical Sciences, Beijing, People's Republic of China.
  • Zhu LL; Beijing Institute of Basic Medical Sciences, Beijing, People's Republic of China.
Stem Cells Dev ; 33(13-14): 333-342, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38753713
ABSTRACT
The proliferation of neural stem cells (NSCs) is precisely regulated by extracellular environmental factors. In situ hypoxia, one of the key factors involved in the regulation of NSC characteristics, has attracted increasing amounts of attention. Numerous studies have demonstrated that hypoxia can significantly promote the formation of neurospheres and the proliferation of NSCs in vitro and that intermittent hypoxia can promote the proliferation of endogenous NSCs in vivo. In this article, the effects of different concentrations of oxygen on NSC proliferation and differentiation both in vivo and in vitro are reviewed, and the potential applications of hypoxia-preconditioned NSCs, as well as research progress and challenges in the treatment of central nervous system diseases, are further summarized. Here, the critical role of oxygen in the neurogenesis of NSCs is emphasized, and insights into the use of hypoxia to regulate NSC characteristics are provided.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipóxia Celular / Proliferação de Células / Neurogênese / Células-Tronco Neurais Limite: Animals / Humans Idioma: En Revista: Stem Cells Dev Assunto da revista: HEMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipóxia Celular / Proliferação de Células / Neurogênese / Células-Tronco Neurais Limite: Animals / Humans Idioma: En Revista: Stem Cells Dev Assunto da revista: HEMATOLOGIA Ano de publicação: 2024 Tipo de documento: Article