Variation of resection margins in oral cancer in dependence of tumor stage and subsite - a retrospective cohort study.
Clin Oral Investig
; 28(6): 327, 2024 May 20.
Article
em En
| MEDLINE
| ID: mdl-38764079
ABSTRACT
OBJECTIVES:
Surgical resection is a key component of the treatment of head and neck cancer and the achievement of free surgical margins are essential for the patients' outcome in terms of survival. While there is a general recommendation for a free resection range of 5 mm, up to date, there is a lack of investigations on the quality of tumor resection in dependence of affected subsite and tumor stage. In the presented study, predictors for the achieved resection margins in surgically treated oral squamous cell carcinomas were analyzed. MATERIALS ANDMETHODS:
A cohort of 567 patients was included in a retrospective analysis and resection status with exact margin ranges were analysed. Tumor stage, affected subsite and the results of the intraoperative frozen section analysis were assessed. Primary endpoint was the achieved resection margin in mm, secondary endpoints were overall and progression-free survival.RESULTS:
The observed mean values of minimal resection margins differed significantly between the investigated subsites (p = 0.042),pathological tumor stages (p < 0.001) and in tumors which demonstrated perineural infiltration (Pn1, p = 0.002). Furthermore, there was a significant impact of the results of the intraoperative frozen section analysis on progression-free and overall survival (p < 0.001).CONCLUSIONS:
Our data clearly indicate that resection status differs between tumors of different subsites and tumor stages. CLINICAL RELEVANCE Clinical procedures should be adapted in order to achieve similar certainty in all resections, and, thus to improve patients' outcome.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
/
Margens de Excisão
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Secções Congeladas
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Estadiamento de Neoplasias
Limite:
Adult
/
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Oral Investig
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Alemanha