Risk Factors for Postoperative Complications of Laparoscopic Right Colectomy: A Post Hoc Analysis of RELARC Trial.

ABSTRACT

BACKGROUND: There is concern regarding the possibility of postoperative complications for laparoscopic right colectomy. OBJECTIVE: To evaluate the risk factors of postoperative complications for patients undergoing laparoscopic right colectomy. DESIGN: This was an observational study. SETTINGS This was a post-hoc analysis of a prospective, multicenter, randomized controlled trial (RELARC trial, NCT02619942). PATIENTS Patients included in the modified intention-to-treat analysis in RELARC trial were all enrolled in this study. MAIN OUTCOME MEASURES: Risk factors for postoperative complications were identified using univariate and multivariable logistic regression analysis. RESULTS: Of 995 patients, 206 (20.7%) had postoperative complications. Comorbidity (p = 0.02, OR 1.544, 95% CI 1.077-2.212) and operative time >180 min (p = 0.03, OR 1.453, 95% CI 1.032-2.044) were independent risk factors for postoperative complications. While female (p = 0.04, OR 0.704, 95% CI 0.506-0.980) and extracorporeal anastomosis (p < 0.001, OR 0.251, 95% CI 0.166-0.378) were protective factors. Eighty (8.0%) had overall surgical site infection, 53 (5.3%) had incisional SSI, and 33 (3.3%) had organ/space SSI. Side-to-side anastomosis was a risk factor for overall surgical site infection (p < 0.001, OR 1.912, 95% CI 1.118-3.268) and organ/space surgical site infection (p = 0.005, OR 3.579, 95% CI 1.455-8.805). Extracorporeal anastomosis was associated with a reduced risk of overall surgical site infection (p < 0.001, OR 0.239, 95% CI 0.138-0.413), organ/space surgical site infection (p = 0.002 OR 0.296, 95% CI 0.136-0.646), and incisional surgical site infection (p < 0.001, OR 0.179, 95% CI 0.099-0.322). Diabetes (p = 0.039 OR 2.090, 95% CI 1.039-4.205) and conversion to open surgery (p = 0.013 OR 5.403, 95% CI 1.437-20.319) were risk factors for incisional surgical site infection. LIMITATIONS: Due to the retrospective nature, the key limitation is the lack of prospective documentation and standardization about perioperative management of these patients such as preoperative optimization, bowel prep regimes and antibiotic regimes, which may be confounder factors of complications. All surgeries were done by experienced surgeons and the patients enrolled were relatively young, generally healthy, and non-obese. It is unclear whether the results will be generalizable to obese and other populations worldwide. CONCLUSIONS: Male, comorbidity, prolonged operative time, and intracorporeal anastomosis were independent risk factors of postoperative complications of laparoscopic right colectomy. Side-to-side anastomosis was associated with an increased risk of organ/space surgical site infection. Extracorporeal anastomosis could reduce the incidence of overall surgical site infection. Diabetes and conversion to open surgery were associated with an increased risk of incisional surgical site infection. See Video Abstract.