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Novel kinase 1 regulates CD8+T cells as a potential therapeutic mechanism for idiopathic pulmonary fibrosis.
Tan, Zhen-Yuan; Lou, Yuan; Qin, Yu-Cui; Lin, Wei; Liang, Bin-Bin; Sooranna, Suren R; Ma, Yi-Li; Zhou, Su-Fang.
Afiliação
  • Tan ZY; School of Basic Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
  • Lou Y; The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi 530021, China.
  • Qin YC; School of Basic Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
  • Lin W; School of Basic Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
  • Liang BB; School of Basic Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
  • Sooranna SR; Department of Metabolism, Digestion and Reproduction Faculty of Medicine Imperial College London Chelsea & Westminster Hospital, London SW10 9NH, UK.
  • Ma YL; Life Science and Clinical Research Center, Youjiang Medical University for Nationalities,18 Zhongshan Road II, Baise 533000, Guangxi, China.
  • Zhou SF; School of Basic Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Int J Med Sci ; 21(6): 1079-1090, 2024.
Article em En | MEDLINE | ID: mdl-38774751
ABSTRACT
Idiopathic pulmonary fibrosis (IPF) is a rare, chronic and progressively worsening lung disease that poses a significant threat to patient prognosis, with a mortality rate exceeding that of some common malignancies. Effective methods for early diagnosis and treatment remain for this condition are elusive. In our study, we used the GEO database to access second-generation sequencing data and associated clinical information from IPF patients. By utilizing bioinformatics techniques, we identified crucial disease-related genes and their biological functions, and characterized their expression patterns. Furthermore, we mapped out the immune landscape of IPF, which revealed potential roles for novel kinase 1 and CD8+T cells in disease progression and outcome. These findings can aid the development of new strategies for the clinical diagnosis and treatment of IPF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Fibrose Pulmonar Idiopática Limite: Humans Idioma: En Revista: Int J Med Sci Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Fibrose Pulmonar Idiopática Limite: Humans Idioma: En Revista: Int J Med Sci Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China